Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.62 |
| ▸ | GSK3A | P49840 | 14/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATR | Q13535 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205114 | 0.84 | GSK3B (0.75) | GSK3BGSK3AMAPTATRJAK2 | |
| SCHEMBL20205207 | 0.83 | GSK3B (0.61) | GSK3BGSK3AMAPTATR | |
| SCHEMBL20204995 | 0.82 | GSK3B (0.70) | GSK3BGSK3AMAPTATRJAK2 | |
| SCHEMBL20189134 | 0.81 | GSK3B (0.74) | GSK3BGSK3AMAPTATRJAK2 | |
| SCHEMBL20205158 | 0.80 | GSK3B (0.71) | GSK3BGSK3AMAPTATRJAK2 | |
| SCHEMBL20205171 | 0.79 | GSK3B (0.76) | GSK3BGSK3AMAPTATRJAK2 | |
| SCHEMBL20205110 | 0.79 | GSK3A (0.79) | GSK3BGSK3AMAPTATR | |
| SCHEMBL20189564 | 0.79 | GSK3B (0.65) | GSK3BGSK3AMAPTATRJAK2 | |
| SCHEMBL20205058 | 0.78 | GSK3B (0.69) | GSK3BGSK3AMAPTATRJAK2 | |
| SCHEMBL20205202 | 0.78 | GSK3B (0.69) | GSK3BGSK3AMAPTATRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544613-A1 | GSK-3 INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018098412-A1 | GSK-3 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-31 | — | — | WO | disclosed |