Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30114963 | 0.95 | ABL1 (0.45) | ABL1KITBCR | |
| SCHEMBL21799101 | 0.95 | ABL1 (0.45) | ABL1KITBCR | |
| SCHEMBL20188193 | 0.86 | ABL1 (0.52) | AXLABL1KITBCR | |
| SCHEMBL30530303 | 0.84 | MLNR (0.39) | ABL1KITBCR | |
| SCHEMBL21799136 | 0.83 | ABL1 (0.48) | SCN9AWDR5ABL1WNT3A | |
| SCHEMBL30530284 | 0.83 | ABL1 (0.48) | SCN9AWDR5ABL1WNT3A | |
| SCHEMBL21799047 | 0.82 | ABL1 (0.46) | WDR5ABL1BCRWNT3A | |
| SCHEMBL30530288 | 0.82 | ABL1 (0.46) | WDR5ABL1BCRWNT3A | |
| SCHEMBL20190689 | 0.81 | ABL1 (0.41) | ABL1 | |
| SCHEMBL20188788 | 0.80 | ABL1 (0.49) | AXLABL1KITBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793542-B2 | Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2020-10-06 | — | — | US | disclosed |
| US-20200079753-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2020-03-12 | — | — | US | disclosed |
| EP-3544685-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | Development Center for Biotechnology (TW) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018098250-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079753-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | SHH, GLI1, SMO | SCN9A 3728/4885WDR5 1515/4885PTK2 1634/4885 |
| US-10793542-B2 | Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof | SHH, GLI1, NR1H4 | SCN9A 3320/4885WDR5 1442/4885PTK2 1769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.