Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 8/20 | 0.86 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.80 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.56 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | CDK14 | O94921 | 1/20 | 0.42 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20190995 | 0.93 | IRAK1 (1.00) | IRAK1MAP3K19IRAK4BCAT2EGFR | |
| SCHEMBL20206093 | 0.89 | IRAK1 (1.00) | IRAK1MAP3K19IRAK4BCAT2EGFR | |
| SCHEMBL20206218 | 0.89 | IRAK1 (1.00) | IRAK1MAP3K19IRAK4BCAT2EGFR | |
| SCHEMBL20206219 | 0.85 | IRAK1 (1.00) | IRAK1MAP3K19IRAK4BCAT2EGFR | |
| SCHEMBL20206153 | 0.83 | IRAK1 (0.75) | IRAK1MAP3K19IRAK4BCAT2EGFR | |
| SCHEMBL20206143 | 0.82 | IRAK1 (0.68) | IRAK1MAP3K19IRAK4BCAT2 | |
| SCHEMBL24021462 | 0.82 | IRAK1 (0.68) | IRAK1MAP3K19IRAK4BCAT2ATR | |
| SCHEMBL20206262 | 0.82 | IRAK1 (0.68) | IRAK1MAP3K19IRAK4BCAT2ATR | |
| SCHEMBL24021451 | 0.82 | IRAK1 (0.67) | IRAK1MAP3K19IRAK4BCAT2ATR | |
| SCHEMBL21328552 | 0.81 | IRAK1 (0.76) | IRAK1MAP3K19IRAK4BCAT2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544970-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018098367-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |