Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 5/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12807240 | 0.94 | TLR2 (0.47) | TLR2MDM4TP53MDM2TLR1 | |
| SCHEMBL16538935 | 0.93 | TLR2 (0.49) | TLR2MDM4TP53MDM2TLR1 | |
| SCHEMBL27153081 | 0.93 | TLR2 (0.50) | TLR2MDM4TP53MDM2 | |
| SCHEMBL30771499 | 0.93 | TLR2 (0.50) | TLR2MDM4TP53MDM2 | |
| SCHEMBL31296168 | 0.93 | TLR2 (0.50) | TLR2MDM4TP53MDM2 | |
| SCHEMBL30771460 | 0.93 | TLR2 (0.50) | TLR2MDM4TP53MDM2 | |
| SCHEMBL30771405 | 0.93 | TLR2 (0.50) | TLR2MDM4TP53MDM2 | |
| SCHEMBL15147181 | 0.92 | TLR2 (0.46) | TLR2MDM4TP53MDM2TLR1 | |
| SCHEMBL25446060 | 0.91 | TLR2 (0.48) | TLR2MDM4TP53MDM2 | |
| SCHEMBL31267179 | 0.91 | TLR2 (0.51) | TLR2MDM4TP53MDM2TLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9982017-B2 | Synthetic apelin mimetics for the treatment of heart failure | NOVARTIS AG (CH) | 2018-05-29 | — | — | US | disclosed |