Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17472006 | 1.00 | PTPN1 (0.67) | PTPN1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL14130013 | 0.96 | MAPT (0.68) | PTPN1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL30963829 | 0.93 | MAPT (0.72) | PTPN1MAPTMEN1KMT2AHTT | |
| SCHEMBL1985170 | 0.91 | MAPT (0.69) | PTPN1MAPTMEN1KMT2AHTT | |
| SCHEMBL14130392 | 0.88 | PTPN1 (0.72) | PTPN1MAPTMEN1KMT2AHTT | |
| SCHEMBL14130163 | 0.87 | MEN1 (0.70) | PTPN1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL1315526 | 0.86 | PTPN1 (0.87) | PTPN1HDAC2HDAC8HDAC6MEN1 | |
| SCHEMBL9157485 | 0.85 | PTPN1 (0.67) | PTPN1HDAC2HDAC8HDAC6MEN1 | |
| SCHEMBL14130010 | 0.84 | KMT2A (0.81) | PTPN1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL14715847 | 0.84 | PTPN1 (0.84) | PTPN1HDAC2HDAC8HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970107-B1 | PHOTOSWITCHABLE HDAC INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11596691-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2023-03-07 | — | — | US | disclosed |
| US-20210162048-A1 | Photoswitchable HDAC Inhibitors | THE GENERAL HOSPITAL CORPORATION | 2021-06-03 | — | — | US | disclosed |
| US-10828367-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190070295-A1 | Photoswitchable HDAC Inhibitors | THE GENERAL HOSPITAL CORPORATION | 2019-03-07 | — | — | US | disclosed |
| US-9981038-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2018-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190070295-A1 | Photoswitchable HDAC Inhibitors | HDAC4, HDAC1, HDAC3 | PTPN1 2984/4885HDAC2 7/4885HDAC8 4/4885 |
| US-20210162048-A1 | Photoswitchable HDAC Inhibitors | HDAC4, HDAC1, HDAC3 | PTPN1 2984/4885HDAC2 7/4885HDAC8 4/4885 |
| US-11596691-B2 | Photoswitchable HDAC inhibitors | HDAC4, HDAC1, HDAC3 | PTPN1 2984/4885HDAC2 7/4885HDAC8 4/4885 |
| US-10828367-B2 | Photoswitchable HDAC inhibitors | HDAC4, HDAC1, HDAC3 | PTPN1 2984/4885HDAC2 7/4885HDAC8 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.