Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 6/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | RHOA | P61586 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | ALPI | P09923 | 1/20 | 0.30 |
| ▸ | ALPG | P10696 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194179 | 0.86 | F10 (0.44) | AAK1EGFRERBB2 | |
| SCHEMBL20194170 | 0.84 | F10 (0.37) | AAK1EGFRERBB2 | |
| SCHEMBL20194187 | 0.82 | CCR3 (0.34) | AAK1EGFRERBB2 | |
| SCHEMBL20194162 | 0.82 | F10 (0.34) | AAK1EGFRERBB2 | |
| SCHEMBL20194169 | 0.82 | AAK1 (0.51) | AAK1EGFRERBB2ALPLALPI | |
| SCHEMBL20194163 | 0.81 | AAK1 (0.38) | AAK1EGFRERBB2ALPLALPI | |
| SCHEMBL20194195 | 0.81 | F10 (0.36) | AAK1ACKR3ALPL | |
| SCHEMBL20194226 | 0.80 | AAK1 (0.33) | AAK1EGFRERBB2ALPL | |
| SCHEMBL20194180 | 0.79 | F10 (0.35) | AAK1EGFRACKR3 | |
| SCHEMBL20194227 | 0.79 | AAK1 (0.51) | AAK1RHOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |