Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | HPN | P05981 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 6/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | NPY2R | P49146 | 1/20 | 0.31 |
| ▸ | UBE2M | P61081 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194180 | 0.94 | F10 (0.35) | F10HPNPRSS1PRSS2PRSS3 | |
| SCHEMBL20194195 | 0.88 | F10 (0.36) | F10HPNPRSS1PRSS2PRSS3 | |
| SCHEMBL20194230 | 0.85 | ACKR3 (0.38) | ACKR3 | |
| SCHEMBL20194193 | 0.85 | F10 (0.36) | F10HPNPRSS1PRSS2PRSS3 | |
| SCHEMBL20194179 | 0.84 | F10 (0.44) | F10HPNPRSS1PRSS2PRSS3 | |
| SCHEMBL20194187 | 0.82 | CCR3 (0.34) | F10HPNPRSS1PRSS2PRSS3 | |
| SCHEMBL20194170 | 0.82 | F10 (0.37) | F10HPNPRSS1PRSS2PRSS3 | |
| SCHEMBL20194226 | 0.81 | AAK1 (0.33) | F10HPNPRSS1PRSS2PRSS3 | |
| SCHEMBL20194167 | 0.80 | F10 (0.37) | F10HPNPRSS1PRSS2PRSS3 | |
| SCHEMBL20194162 | 0.80 | F10 (0.34) | F10HPNPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |