Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.55 |
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194194 | 0.88 | AAK1 (0.63) | AAK1ERBB2EGFR | |
| SCHEMBL20194165 | 0.83 | AAK1 (0.63) | AAK1ERBB2EGFR | |
| SCHEMBL1219964 | 0.81 | EGFR (0.75) | AAK1ERBB2EGFR | |
| SCHEMBL20194241 | 0.80 | AAK1 (0.62) | AAK1ERBB2EGFR | |
| SCHEMBL1218675 | 0.80 | ERBB2 (0.76) | AAK1ERBB2EGFR | |
| SCHEMBL20194182 | 0.80 | AAK1 (0.61) | AAK1ERBB2EGFR | |
| SCHEMBL16636709 | 0.78 | AAK1 (1.00) | AAK1ERBB2EGFR | |
| SCHEMBL20194232 | 0.77 | AAK1 (0.65) | AAK1ERBB2EGFR | |
| SCHEMBL1219685 | 0.77 | EGFR (0.74) | AAK1ERBB2EGFR | |
| SCHEMBL20194242 | 0.77 | AAK1 (0.64) | AAK1ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |