Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.36 |
| ▸ | PLG | P00747 | 4/20 | 0.36 |
| ▸ | PLAU | P00749 | 3/20 | 0.36 |
| ▸ | PLAT | P00750 | 3/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.30 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194237 | 0.86 | PRSS1 (0.33) | F2PRSS1PLGAAK1PRSS2 | |
| SCHEMBL20194196 | 0.85 | AAK1 (0.32) | PRSS1AAK1PRSS2PRSS3ST14 | |
| SCHEMBL20194179 | 0.84 | F10 (0.44) | F2PRSS1AAK1PRSS2PRSS3 | |
| SCHEMBL20194187 | 0.77 | CCR3 (0.34) | PRSS1AAK1PRSS2PRSS3ST14 | |
| SCHEMBL20194170 | 0.77 | F10 (0.37) | PRSS1AAK1PRSS2PRSS3ST14 | |
| SCHEMBL20194185 | 0.77 | F10 (0.46) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL20194243 | 0.76 | F10 (0.42) | F2PRSS1AAK1PRSS2PRSS3 | |
| SCHEMBL20194162 | 0.75 | F10 (0.34) | PRSS1AAK1PRSS2PRSS3ST14 | |
| SCHEMBL20194226 | 0.75 | AAK1 (0.33) | PRSS1AAK1PRSS2PRSS3ST14 | |
| SCHEMBL20194180 | 0.74 | F10 (0.35) | PRSS1AAK1PRSS2PRSS3ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |