Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 14/20 | 0.61 |
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194207 | 0.90 | AAK1 (0.60) | AAK1EGFRERBB2CITCHEK1 | |
| SCHEMBL20194160 | 0.86 | EGFR (0.69) | AAK1EGFRERBB2 | |
| SCHEMBL20194229 | 0.85 | AAK1 (0.64) | AAK1EGFRERBB2 | |
| SCHEMBL20194202 | 0.80 | AAK1 (0.62) | AAK1EGFRERBB2CITCHEK1 | |
| SCHEMBL20194186 | 0.77 | EGFR (0.72) | AAK1EGFRERBB2 | |
| SCHEMBL20194201 | 0.76 | AAK1 (0.65) | AAK1EGFRERBB2 | |
| SCHEMBL16636314 | 0.76 | AAK1 (1.00) | AAK1 | |
| SCHEMBL16636358 | 0.76 | AAK1 (1.00) | AAK1 | |
| SCHEMBL20194225 | 0.75 | EGFR (0.68) | AAK1EGFRERBB2 | |
| SCHEMBL16636553 | 0.74 | AAK1 (1.00) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |