Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 18/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194231 | 0.92 | AAK1 (0.54) | AAK1POLBKMT2A | |
| SCHEMBL20194220 | 0.91 | AAK1 (0.54) | AAK1POLBKMT2A | |
| SCHEMBL20194217 | 0.89 | AAK1 (0.53) | AAK1POLBKMT2A | |
| SCHEMBL20194200 | 0.89 | AAK1 (0.55) | AAK1POLB | |
| SCHEMBL20194183 | 0.88 | AAK1 (0.52) | AAK1POLBKMT2A | |
| SCHEMBL20194218 | 0.87 | AAK1 (0.54) | AAK1 | |
| SCHEMBL20194191 | 0.79 | AAK1 (0.49) | AAK1 | |
| SCHEMBL20194219 | 0.79 | AAK1 (0.50) | AAK1 | |
| SCHEMBL20194163 | 0.78 | AAK1 (0.38) | AAK1POLBKMT2A | |
| SCHEMBL20194155 | 0.78 | AAK1 (0.53) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |