Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.72 |
| ▸ | EGFR | P00533 | 15/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194198 | 0.91 | AAK1 (0.70) | AAK1EGFRERBB2LCKKDR | |
| SCHEMBL1220119 | 0.85 | AAK1 (0.80) | AAK1EGFRERBB2LCKKDR | |
| SCHEMBL16646766 | 0.84 | AAK1 (1.00) | AAK1EGFRERBB2LCKKDR | |
| SCHEMBL14017663 | 0.84 | AAK1 (0.74) | AAK1EGFRERBB2LCKKDR | |
| SCHEMBL16646843 | 0.82 | AAK1 (0.73) | AAK1EGFRERBB2LCK | |
| SCHEMBL16646787 | 0.82 | AAK1 (0.72) | AAK1EGFRERBB2LCKKDR | |
| SCHEMBL16646791 | 0.80 | AAK1 (0.75) | AAK1EGFRERBB2LCKKDR | |
| SCHEMBL16646789 | 0.79 | AAK1 (0.70) | AAK1EGFRERBB2LCKKDR | |
| SCHEMBL16646788 | 0.78 | AAK1 (1.00) | AAK1EGFRERBB2LCKKDR | |
| SCHEMBL20194171 | 0.77 | ERBB2 (0.64) | AAK1EGFRERBB2LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |