Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22891776 | 0.77 | TSHR (0.36) | TSHRALDH1A1CYP3A4 | |
| SCHEMBL26486559 | 0.72 | TSHR (0.42) | TSHRALDH1A1 | |
| SCHEMBL22043815 | 0.70 | TSHR (0.43) | TSHRALDH1A1 | |
| SCHEMBL26566583 | 0.70 | SLC1A3 (0.32) | ALDH1A1MEN1CYP3A4KMT2A | |
| SCHEMBL23197649 | 0.69 | TSHR (0.41) | TSHRALDH1A1 | |
| SCHEMBL3120232 | 0.69 | TSHR (0.56) | TSHRALDH1A1CYP3A4 | |
| SCHEMBL1907970 | 0.68 | TSHR (0.62) | TSHRALDH1A1CYP3A4PLA2G2C | |
| SCHEMBL22349935 | 0.67 | MEN1 (0.30) | MEN1CYP3A4KMT2A | |
| SCHEMBL22157421 | 0.67 | TSHR (0.59) | TSHRALDH1A1 | |
| SCHEMBL1904603 | 0.67 | TSHR (0.59) | TSHRALDH1A1MEN1CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327013-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | Celgene Corporation (US) | 2018-05-30 | — | — | EP | disclosed |