Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | GFER | P55789 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18856585 | 0.86 | JAK2 (0.73) | JAK2GAAGFERMEN1KMT2A | |
| SCHEMBL18856592 | 0.86 | JAK2 (0.64) | JAK2GAAGFERMEN1KMT2A | |
| SCHEMBL20194900 | 0.82 | JAK2 (0.64) | JAK2GAAGFERMEN1KMT2A | |
| SCHEMBL15544102 | 0.81 | GAA (0.59) | JAK2GAAGFERMEN1KMT2A | |
| SCHEMBL18856766 | 0.81 | JAK2 (0.68) | JAK2GAAGFERMEN1KMT2A | |
| SCHEMBL18856611 | 0.79 | JAK2 (0.56) | JAK2GAAGFERMEN1KMT2A | |
| SCHEMBL15606404 | 0.79 | GAA (0.71) | GAAGFERMEN1KMT2AMAPT | |
| SCHEMBL16014481 | 0.79 | GAA (0.65) | JAK2GAAGFERMEN1KMT2A | |
| SCHEMBL18856549 | 0.79 | GAA (0.70) | JAK2GAAGFERMEN1KMT2A | |
| SCHEMBL15606376 | 0.78 | JAK2 (0.55) | JAK2GAAGFERMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964634-B1 | ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-05-30 | — | — | EP | disclosed |