Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 15/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SREBF1 | P36956 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20197347 | 0.89 | SREBF2 (0.55) | SREBF2MAPTKDM4ESREBF1ALDH1A1 | |
| SCHEMBL22152727 | 0.84 | SREBF2 (0.43) | SREBF2MAPTKDM4ESREBF1ALDH1A1 | |
| SCHEMBL20197323 | 0.84 | SREBF2 (0.46) | SREBF2MAPTKDM4ESREBF1ALDH1A1 | |
| SCHEMBL20197208 | 0.84 | SREBF2 (0.43) | SREBF2MAPTKDM4ESREBF1ALDH1A1 | |
| SCHEMBL16535189 | 0.83 | SREBF2 (0.47) | SREBF2MAPTSMN1; SMN2HTTKDM4E | |
| SCHEMBL20197360 | 0.83 | SREBF2 (0.48) | SREBF2MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20197405 | 0.81 | SREBF2 (0.42) | SREBF2MAPTKDM4ESREBF1ALDH1A1 | |
| SCHEMBL16544537 | 0.80 | SREBF2 (0.60) | SREBF2MAPTSMN1; SMN2HTTKDM4E | |
| SCHEMBL20197194 | 0.77 | SREBF2 (0.39) | SREBF2MAPTKDM4ESREBF1ALDH1A1 | |
| SCHEMBL20197300 | 0.76 | SREBF2 (0.67) | SREBF2MAPTKDM4ESREBF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |