Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 12/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30051403 | 0.87 | GSK3A (0.77) | GSK3AMAPTGSK3B | |
| SCHEMBL20199770 | 0.87 | GSK3A (0.77) | GSK3AMAPTGSK3B | |
| SCHEMBL30051421 | 0.87 | GSK3A (0.68) | GSK3AMAPTGSK3BATRIRAK4 | |
| SCHEMBL20199628 | 0.87 | GSK3A (0.68) | GSK3AMAPTGSK3BATRIRAK4 | |
| SCHEMBL30050805 | 0.86 | GSK3A (1.00) | GSK3AMAPTGSK3BATR | |
| SCHEMBL20199658 | 0.86 | GSK3A (1.00) | GSK3AMAPTGSK3BATR | |
| SCHEMBL20199492 | 0.85 | GSK3A (0.74) | GSK3AMAPTGSK3B | |
| SCHEMBL30050851 | 0.85 | GSK3A (0.74) | GSK3AMAPTGSK3B | |
| SCHEMBL20199415 | 0.74 | GSK3A (1.00) | GSK3AMAPTGSK3B | |
| SCHEMBL20199821 | 0.71 | GSK3A (1.00) | GSK3AMAPTGSK3BATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098411-A1 | GSK-3 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-31 | — | — | WO | disclosed |