SCHEMBL2020178

SCHEMBL2020178

O=C1NC(=S)N/C1=C\c1ccc(-c2ccc(Cl)cc2)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRF1 P14222 20/20 1.00
TOP1 P11387 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2020179 1.00 PRF1 (1.00) PRF1TOP1
SCHEMBL2043959 1.00 PRF1 (1.00) PRF1TOP1
SCHEMBL12634251 0.87 PRF1 (1.00) PRF1TOP1
SCHEMBL14761474 0.87 PRF1 (1.00) PRF1TOP1
SCHEMBL2038862 0.86 PRF1 (1.00) PRF1TOP1
SCHEMBL2038597 0.86 PRF1 (1.00) PRF1TOP1
SCHEMBL2038859 0.86 PRF1 (1.00) PRF1TOP1
SCHEMBL2038596 0.86 PRF1 (1.00) PRF1TOP1
SCHEMBL14761177 0.86 PRF1 (1.00) PRF1TOP1
SCHEMBL2038593 0.86 PRF1 (1.00) PRF1TOP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011075784-A1 COMPOUNDS, PREPARATIONS AND USES THEREOF PETER MACCALLUM CANCER INSTITUTE (AU) 2011-06-30 WO claimed
EP-2515903-A1 COMPOUNDS, PREPARATIONS AND USES THEREOF Peter MacCallum Cancer Institute (AU) 2012-10-31 EP disclosed
WO-2011075784-A1 COMPOUNDS, PREPARATIONS AND USES THEREOF PETER MACCALLUM CANCER INSTITUTE (AU) 2011-06-30 WO disclosed