Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 13/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18290696 | 0.90 | PDE2A (0.49) | PDE2A | |
| SCHEMBL20202574 | 0.83 | RET (0.45) | PDE2ARETRIPK2ALOX5MAPT | |
| SCHEMBL20150745 | 0.81 | PDE2A (0.46) | PDE2ARETALOX5MAPT | |
| SCHEMBL18282858 | 0.80 | PDE2A (0.49) | PDE2A | |
| SCHEMBL20150749 | 0.77 | PDE2A (0.52) | PDE2A | |
| SCHEMBL18291853 | 0.76 | PDE2A (0.53) | PDE2A | |
| SCHEMBL20150756 | 0.75 | PDE2A (0.50) | PDE2A | |
| SCHEMBL18291879 | 0.75 | PDE2A (0.52) | PDE2A | |
| SCHEMBL20150754 | 0.73 | PDE2A (0.48) | PDE2ARET | |
| SCHEMBL18290668 | 0.73 | PDE2A (0.53) | PDE2ARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148453-A1 | DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148453-A1 | DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | PDE12, PDE2A, PDE4D | PDE2A 2/4885RET 1879/4885RIPK2 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.