SCHEMBL20203901 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	CYP1A2	P05177	6/20	0.60

▸	SCN5A	Q14524	5/20	0.60

▸	MET	P08581	4/20	0.39

▸	CYP3A4	P08684	2/20	0.39

▸	SCN1A	P35498	1/20	0.39

▸	SCN2A	Q99250	1/20	0.39

▸	DYRK1A	Q13627	4/20	0.38

▸	CLK2	P49760	1/20	0.37

▸	HASPIN	Q8TF76	1/20	0.37

▸	KDM4E	B2RXH2	1/20	0.37

▸	MEN1	O00255	1/20	0.37

▸	ALDH1A1	P00352	1/20	0.37

▸	KMT2A	Q03164	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL937513	0.82	CYP1A2 (0.70)	CYP1A2SCN5ASCN1ASCN2ADYRK1A
SCHEMBL26538943	0.79	CYP1A2 (0.82)	CYP1A2SCN5AMETCYP3A4SCN1A
SCHEMBL20203793	0.79	CYP1A2 (0.65)	CYP1A2SCN5AMETCYP3A4SCN1A
SCHEMBL26538864	0.78	CYP1A2 (0.58)	CYP1A2SCN5AMETCYP3A4KDM4E
SCHEMBL26539011	0.76	CYP1A2 (0.77)	CYP1A2SCN5AMETSCN1ASCN2A
SCHEMBL20203741	0.76	CYP1A2 (0.77)	CYP1A2SCN5AMETSCN1ASCN2A
SCHEMBL20203775	0.76	CYP1A2 (0.76)	CYP1A2SCN5AMETSCN1ASCN2A
SCHEMBL937481	0.76	CYP1A2 (0.75)	CYP1A2SCN5ASCN1ASCN2ADYRK1A
SCHEMBL937201	0.76	CYP1A2 (1.00)	CYP1A2SCN5ASCN1ASCN2ADYRK1A
SCHEMBL20203920	0.74	CYP1A2 (0.77)	CYP1A2SCN5AMETSCN1ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018098499-A1	COMPOUNDS AND THEIR METHODS OF USE	PRAXIS PRECISION MEDICINES, INC. (US)	2018-05-31	—	—	WO	disclosed