Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.84 |
| ▸ | GSK3A | P49840 | 18/20 | 0.84 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204986 | 0.91 | GSK3B (0.85) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20189392 | 0.91 | GSK3A (0.85) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20204982 | 0.91 | GSK3B (1.00) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20205146 | 0.91 | GSK3B (0.78) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20205078 | 0.90 | GSK3B (0.84) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20205038 | 0.90 | GSK3A (1.00) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20189577 | 0.89 | GSK3B (0.81) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20205184 | 0.89 | GSK3B (0.81) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20190071 | 0.88 | GSK3B (0.80) | GSK3BGSK3AJAK2PIM1CDK2 | |
| SCHEMBL20190741 | 0.88 | GSK3A (1.00) | GSK3BGSK3AJAK2PIM1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098412-A1 | GSK-3 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-31 | — | — | WO | disclosed |