Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 11/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | MIF | P14174 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | OGT | O15294 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021384 | 0.85 | APP (0.55) | APPDRD2DRD4DRD3MIF | |
| SCHEMBL12573360 | 0.85 | APP (0.55) | APPDRD2DRD4DRD3MIF | |
| SCHEMBL14048157 | 0.85 | APP (0.55) | APPDRD2DRD4DRD3MIF | |
| SCHEMBL1251566 | 0.78 | APP (0.64) | APPMAPTSNCA | |
| SCHEMBL1251526 | 0.78 | APP (0.64) | APPMAPTSNCA | |
| SCHEMBL2025936 | 0.77 | APP (0.51) | APPDRD2DRD4DRD3MIF | |
| SCHEMBL13453292 | 0.77 | FLT3 (0.56) | DRD2DRD4DRD3MIFPTGS2 | |
| SCHEMBL12573195 | 0.76 | APP (0.55) | APPMIFPTGS2PTGS1CA1 | |
| SCHEMBL12573172 | 0.75 | MIF (0.46) | APPMIFPTGS2PTGS1CA1 | |
| SCHEMBL12573356 | 0.74 | FLT3 (0.66) | PTGS2SNCAPTGS1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110158907-A1 | DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERISTY OF PENNSYLVANIA (US) | 2011-06-30 | — | — | US | disclosed |
| US-20110158907-A1 | DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERISTY OF PENNSYLVANIA (US) | 2011-06-30 | — | — | US | disclosed |
| US-20110158907-A1 | DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERISTY OF PENNSYLVANIA (US) | 2011-06-30 | — | — | US | disclosed |
| WO-2008131148-A1 | DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110158907-A1 | DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | APP, APBA1, BACE2 | APP 1/4885DRD2 1394/4885DRD4 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.