Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158492 | 0.97 | RET (0.40) | RETHRH3SIGMAR1FPR3FPR2 | |
| SCHEMBL20205850 | 0.89 | CYP2C19 (0.41) | RETHRH3FPR3FPR2KDM4E | |
| SCHEMBL20206000 | 0.89 | KDM4E (0.45) | RETKDM4ECYP2D6CYP2C19 | |
| SCHEMBL21652001 | 0.88 | RET (0.42) | RETHRH3 | |
| SCHEMBL20069776 | 0.87 | CYP2C19 (0.40) | RETHRH3FPR3FPR2KDM4E | |
| SCHEMBL22856993 | 0.86 | RET (0.41) | RETKDM4ECYP2D6CYP2C19 | |
| SCHEMBL20069795 | 0.84 | CYP2C19 (0.40) | RETSIGMAR1FPR3FPR2KDM4E | |
| SCHEMBL20158491 | 0.84 | RET (0.43) | RETKDM4E | |
| SCHEMBL20148014 | 0.82 | RET (0.37) | RETHRH3FPR3FPR2KDM4E | |
| SCHEMBL20070272 | 0.82 | RET (0.36) | RETHRH3FPR3FPR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | RET 1/4885HRH3 1000/4885SIGMAR1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.