⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12885832 | 0.86 | — | — | |
| SCHEMBL14508376 | 0.86 | — | — | |
| SCHEMBL4757567 | 0.86 | — | — | |
| SCHEMBL24490873 | 0.80 | ATM (0.33) | — | |
| SCHEMBL20920499 | 0.80 | ATM (0.33) | — | |
| SCHEMBL20413242 | 0.79 | — | — | |
| SCHEMBL26163014 | 0.77 | SMN1; SMN2 (0.30) | — | |
| SCHEMBL26842301 | 0.77 | HRH3 (0.31) | — | |
| SCHEMBL26396225 | 0.77 | GLB1 (0.35) | — | |
| SCHEMBL18683419 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10441581-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-31 | — | — | US | disclosed |