Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 6/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | SCNN1B | P51168 | 1/20 | 0.46 |
| ▸ | SCNN1G | P51170 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12636285 | 0.99 | SCNN1A (0.46) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2015981 | 0.92 | SCNN1A (0.48) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12636676 | 0.91 | SCNN1A (0.48) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2021015 | 0.90 | SCNN1A (0.49) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12636282 | 0.89 | SCNN1A (0.49) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2020245 | 0.87 | SCNN1A (0.50) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2021178 | 0.86 | SCNN1A (0.49) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12634909 | 0.86 | SCNN1A (0.51) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL2015389 | 0.86 | SCNN1A (0.51) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2014385 | 0.85 | SCNN1A (0.43) | SCNN1ADRD5SCNN1BSCNN1GHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |