Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.59 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 10/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935922 | 0.78 | SCN5A (0.60) | DYRK1ASCN5ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL360789 | 0.76 | DYRK1A (0.77) | DYRK1AJAK2RETKDRGSK3A | |
| SCHEMBL3514678 | 0.75 | DYRK1A (0.70) | DYRK1AJAK2RETKDRGSK3A | |
| SCHEMBL21643997 | 0.75 | DYRK1A (1.00) | DYRK1AJAK2RETKDRGSK3A | |
| Hydrochloric Acid SCHEMBL21411936 | 0.74 | DYRK1A (0.68) | DYRK1AJAK2RETKDRGSK3A | |
| SCHEMBL20208546 | 0.74 | SCN5A (0.61) | DYRK1ARETSCN5ACYP1A2KDM4E | |
| SCHEMBL22688959 | 0.73 | KDR (0.59) | DYRK1AJAK2RETKDRGSK3A | |
| SCHEMBL20208560 | 0.73 | KDM4E (0.55) | SCN5ACYP1A2KDM4ENPC1ALDH1A1 | |
| SCHEMBL3515178 | 0.73 | DYRK1A (0.66) | DYRK1AJAK2RETKDRGSK3A | |
| SCHEMBL20208538 | 0.72 | SCN5A (0.64) | DYRK1ASCN5ACYP1A2MAPTSCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188839-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2021-06-24 | — | — | US | disclosed |
| WO-2018098500-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188839-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | DYRK1A 4493/4885JAK2 4127/4885RET 3587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.