Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 10/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | SCNN1B | P51168 | 1/20 | 0.33 |
| ▸ | SCNN1G | P51170 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | THPO | P40225 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | GLA | P06280 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | GMNN | O75496 | 3/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12636297 | 0.99 | SCNN1A (0.33) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2018318 | 0.83 | SCNN1A (0.50) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12635766 | 0.82 | SCNN1A (0.51) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12634871 | 0.80 | GRM5 (0.43) | SCNN1AHSD17B10CYP1A2CYP2D6THPO | |
| SCHEMBL12634866 | 0.76 | SCNN1A (0.46) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2018413 | 0.76 | SCNN1A (0.46) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2018152 | 0.75 | SCNN1A (0.40) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12634881 | 0.75 | SCNN1A (0.47) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2016298 | 0.74 | MEN1 (0.41) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12635770 | 0.74 | SMN1; SMN2 (0.41) | SCNN1AHSD17B10CYP1A2CYP2D6THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |