Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18464191 | 0.87 | CNR2 (0.53) | CNR2CNR1LMNASMN1; SMN2HTT | |
| SCHEMBL20218939 | 0.86 | CNR2 (0.75) | CNR2CNR1LMNASMN1; SMN2HTT | |
| SCHEMBL18464205 | 0.86 | NR1H4 (0.58) | CNR2CNR1LMNASMN1; SMN2NR1H4 | |
| SCHEMBL18464190 | 0.81 | CNR2 (0.47) | CNR2CNR1LMNASMN1; SMN2HTT | |
| SCHEMBL18664784 | 0.78 | NR1H4 (0.65) | NR1H4TDP1 | |
| SCHEMBL29403447 | 0.78 | NR1H4 (0.65) | NR1H4TDP1 | |
| SCHEMBL20518768 | 0.77 | NR1H4 (0.55) | LMNASMN1; SMN2NR1H4TDP1 | |
| SCHEMBL29407024 | 0.77 | NR1H4 (0.55) | LMNASMN1; SMN2NR1H4TDP1 | |
| SCHEMBL7141111 | 0.77 | HTT (0.63) | CNR2CNR1LMNASMN1; SMN2HTT | |
| SCHEMBL157266 | 0.77 | HTT (0.63) | CNR2CNR1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026056-B | 1,3, 4-oxadiazole amide derivative compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions thereof | 株式会社钟根堂 | 2021-08-03 | — | — | CN | disclosed |
| EP-3330259-B1 | 1,3,4-OXADIAZOLE AMIDE DERIVATIVE COMPOUND AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2020-06-10 | — | — | EP | disclosed |
| US-10584117-B2 | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2020-03-10 | — | — | US | disclosed |
| US-20180215743-A1 | 1,3,4-OXADIAZOLE AMIDE DERIVATIVE COMPOUND AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2018-08-02 | — | — | US | disclosed |
| EP-3330259-A1 | 1,3,4-OXADIAZOLE AMIDE DERIVATIVE COMPOUND AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Chong Kun Dang Pharmaceutical Corp. (KR) | 2018-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10584117-B2 | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same | HDAC1, HDAC6, HDAC2 | CNR2 4557/4885CNR1 4563/4885LMNA 3154/4885 |
| US-20180215743-A1 | 1,3,4-OXADIAZOLE AMIDE DERIVATIVE COMPOUND AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | HDAC1, HDAC6, HDAC2 | CNR2 4557/4885CNR1 4563/4885LMNA 3154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.