Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 19/20 | 1.00 |
| ▸ | LITAF | Q99732 | 19/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2022328 | 1.00 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2021087 | 1.00 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| Hydrochloric Acid SCHEMBL2018175 | 0.99 | TNF (0.98) | TNFLITAFPDE4BPDE4D | |
| Hydrochloric Acid SCHEMBL2016007 | 0.99 | TNF (0.98) | TNFLITAFPDE4BPDE4D | |
| Hydrochloric Acid SCHEMBL2016009 | 0.99 | TNF (0.98) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2019680 | 0.95 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| Hydrochloric Acid SCHEMBL2016471 | 0.94 | TNF (0.98) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2019512 | 0.89 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2019671 | 0.89 | TNF (1.00) | TNFLITAFPDE4BPDE4D | |
| SCHEMBL2019461 | 0.87 | TNF (1.00) | TNFLITAFPDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2244574-B1 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF- SYNTHESIS AND AS PDE4 INHIBITORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2014-10-01 | — | — | EP | claimed |
| US-7964608-B2 | Tricyclic compounds as modulators of TNF-α synthesis | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-06-21 | — | — | US | claimed |