Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20213304 | 0.88 | KIT (0.53) | KITMAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL15728505 | 0.87 | MAP4K4 (0.61) | KITMAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL31737149 | 0.86 | KIT (0.55) | KITMAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL656985 | 0.84 | HTT (0.60) | KITMAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL655295 | 0.84 | KIT (0.53) | KITMAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL3885884 | 0.82 | KIT (0.54) | KITMAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL31737885 | 0.80 | MAP4K4 (0.58) | KITMAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL26107084 | 0.80 | KIT (0.48) | KITMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL14782331 | 0.79 | MAP4K4 (0.57) | KITMAP4K4SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2800987 | 0.78 | KIT (0.48) | KITMAP4K4SMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723738-B2 | Inhibitors of KRAS G12C mutant proteins | ARAXES PHARMA LLC (US) | 2020-07-28 | — | — | US | disclosed |
| US-20200062761-A1 | INHIBITORS OF KRAS G12C MUTANT PROTEINS | ARAXES PHARMA LLC | 2020-02-27 | — | — | US | disclosed |
| US-10280172-B2 | Inhibitors of KRAS G12C mutant proteins | ARAXES PHARMA LLC (US) | 2019-05-07 | — | — | US | disclosed |
| US-20180155348-A1 | INHIBITORS OF KRAS G12C MUTANT PROTEINS | ARAXES PHARMA LLC | 2018-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155348-A1 | INHIBITORS OF KRAS G12C MUTANT PROTEINS | KRAS, NRAS, HRAS | KIT 4411/4885MAP4K4 572/4885SMARCA2 876/4885 |
| US-10723738-B2 | Inhibitors of KRAS G12C mutant proteins | KRAS, NRAS, HRAS | KIT 4363/4885MAP4K4 578/4885SMARCA2 868/4885 |
| US-20200062761-A1 | INHIBITORS OF KRAS G12C MUTANT PROTEINS | KRAS, NRAS, HRAS | KIT 4363/4885MAP4K4 578/4885SMARCA2 868/4885 |
| US-10280172-B2 | Inhibitors of KRAS G12C mutant proteins | KRAS, NRAS, HRAS | KIT 4411/4885MAP4K4 572/4885SMARCA2 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.