⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324914 | 0.75 | — | — | |
| SCHEMBL1923502 | 0.75 | — | — | |
| SCHEMBL19434573 | 0.64 | PDE1B (0.32) | — | |
| SCHEMBL4934278 | 0.58 | — | — | |
| SCHEMBL73936 | 0.55 | — | — | |
| SCHEMBL22194798 | 0.55 | — | — | |
| SCHEMBL5821191 | 0.55 | — | — | |
| SCHEMBL10751007 | 0.55 | — | — | |
| SCHEMBL8621147 | 0.55 | — | — | |
| SCHEMBL11414515 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091490-B2 | 3-amino-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones as cyclin dependent kinase inhibitors | MEDIZINISCHE UNIVERSITÄT INNSBRUCK (AT) | 2021-08-17 | — | — | US | disclosed |
| US-11091490-B2 | 3-amino-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones as cyclin dependent kinase inhibitors | MEDIZINISCHE UNIVERSITÄT INNSBRUCK (AT) | 2021-08-17 | — | — | US | disclosed |
| US-20200247809-A1 | 3-AMINO-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AS CYCLIN DEPENDENT KINASE INHIBITORS | ONCOTYROL CENTER FOR PERSONALIZED CANCER MEDICINE GMBH (AT) | 2020-08-06 | — | — | US | disclosed |
| US-20200247809-A1 | 3-AMINO-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AS CYCLIN DEPENDENT KINASE INHIBITORS | ONCOTYROL CENTER FOR PERSONALIZED CANCER MEDICINE GMBH (AT) | 2020-08-06 | — | — | US | disclosed |
| EP-3548488-A1 | 3-AMINO-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AS CYCLIN DEPENDENT KINASE INHIBITORS | Oncotyrol Center for Personalized Cancer Medicine GmbH (AT) | 2019-10-09 | — | — | EP | disclosed |
| EP-3548488-A1 | 3-AMINO-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AS CYCLIN DEPENDENT KINASE INHIBITORS | Oncotyrol Center for Personalized Cancer Medicine GmbH (AT) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018099952-A1 | 3-AMINO-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AS CYCLIN DEPENDENT KINASE INHIBITORS | ONCOTYROL CENTER FOR PERSONALIZED CANCER MEDICINE GMBH (AT) | 2018-06-07 | — | — | WO | disclosed |
| WO-2018099952-A1 | 3-AMINO-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AS CYCLIN DEPENDENT KINASE INHIBITORS | ONCOTYROL CENTER FOR PERSONALIZED CANCER MEDICINE GMBH (AT) | 2018-06-07 | — | — | WO | disclosed |