SCHEMBL20213933

SCHEMBL20213933

N=S(=O)(O)Oc1ccc(Cl)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.47
APEX1 P27695 1/20 0.46
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42
KMO O15229 2/20 0.40
HSD17B10 Q99714 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.39
SCN9A Q15858 3/20 0.38
DAO P14920 1/20 0.38
PPARG P37231 1/20 0.37
PPARA Q07869 1/20 0.37
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37
SCN5A Q14524 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20213993 0.81 APEX1 (0.46) HSP90AA1APEX1CA12CA1CA2
SCHEMBL9871798 0.78 APEX1 (0.50) HSP90AA1APEX1CA12CA1CA2
SCHEMBL27978393 0.70 TDP1 (0.66) APEX1CA12CA2ALDH1A1LMNA
SCHEMBL8072923 0.69 TRPV1 (0.46) HSP90AA1APEX1MRGPRX4SCN5AEPAS1
SCHEMBL11353322 0.68 CYP3A4 (0.56) APEX1CA12CA1CA2CA9
SCHEMBL27709138 0.68 HSP90AA1 (0.54) HSP90AA1KMOHSD17B10PPARGPPARA
SCHEMBL11100175 0.67 KDM4E (0.49) MRGPRX4KDM4EALDH1A1LMNASMN1; SMN2
SCHEMBL4407031 0.67 HSP90AA1 (0.44) HSP90AA1APEX1KMOMRGPRX4DAO
SCHEMBL21820786 0.67 HSP90AA1 (0.71) HSP90AA1KMOSLC6A2SLC6A4SLC6A3
Sulfuric Acid SCHEMBL15569981 0.66 TP53 (0.70) HSD17B10ALDH1A1LMNASLC6A2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3548465-A1 THIONYL TETRAFLUORIDE MODIFIED COMPOUNDS AND USES The Scripps Research Institute (US) 2019-10-09 EP disclosed
WO-2018102433-A1 THIONYL TETRAFLUORIDE MODIFIED COMPOUNDS AND USES THE SCRIPPS RESEARCH INSTITUTE (US) 2018-06-07 WO disclosed