Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 5/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20120517 | 0.86 | SSTR4 (0.41) | SSTR4APP | |
| SCHEMBL20129078 | 0.86 | SSTR4 (0.41) | SSTR4APP | |
| SCHEMBL22638138 | 0.85 | SSTR4 (0.44) | SSTR4S1PR4CYP11B1CYP11B2CNR2 | |
| SCHEMBL29749337 | 0.85 | SSTR4 (0.44) | SSTR4S1PR4CYP11B1CYP11B2CNR2 | |
| SCHEMBL2391289 | 0.85 | SSTR4 (0.46) | SSTR4S1PR4CYP11B1CYP11B2AR | |
| SCHEMBL20129080 | 0.79 | SSTR4 (0.44) | SSTR4APPS1PR4CYP11B1CYP11B2 | |
| SCHEMBL16829682 | 0.77 | SSTR4 (0.41) | SSTR4S1PR4CNR2AAK1 | |
| SCHEMBL2713610 | 0.77 | SSTR4 (0.49) | SSTR4S1PR4CYP11B1CYP11B2KDM4E | |
| SCHEMBL13281923 | 0.76 | SSTR4 (0.52) | SSTR4S1PR4CYP11B1CYP11B2AAK1 | |
| SCHEMBL16829634 | 0.75 | SSTR4 (0.42) | SSTR4S1PR4CYP11B1CYP11B2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999182-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |
| EP-3535265-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| WO-2018102067-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |