Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.53 |
| ▸ | BRD9 | Q9H8M2 | 7/20 | 0.48 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 8/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29547499 | 0.89 | BRD9 (0.47) | BRD9 | |
| SCHEMBL20120867 | 0.89 | BRD9 (0.47) | BRD9 | |
| SCHEMBL20120473 | 0.87 | EGFR (0.48) | BRD9 | |
| SCHEMBL20120641 | 0.86 | BRD9 (0.48) | BRD9 | |
| SCHEMBL23418052 | 0.80 | MAPT (0.55) | DDB1CRBNBRD9 | |
| SCHEMBL30544631 | 0.80 | MAPT (0.55) | DDB1CRBNBRD9 | |
| SCHEMBL20641349 | 0.80 | MAPT (0.55) | DDB1CRBNBRD9 | |
| SCHEMBL29547699 | 0.79 | LRRK2 (0.47) | BRD9 | |
| SCHEMBL20120243 | 0.79 | LRRK2 (0.47) | BRD9 | |
| SCHEMBL23418101 | 0.78 | STAT3 (0.55) | DDB1CRBNBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535265-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| WO-2018102067-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |