SCHEMBL20214744

SCHEMBL20214744

C=Cc1ncc(C)c(CNCCCOc2ccc3c(c2)CC[C@H]3[C@H](C)C(=O)O)n1

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 18/20 0.52
PPARA Q07869 15/20 0.52
PPARD Q03181 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1400507 0.85 PPARA (0.56) PPARGPPARAPPARD
SCHEMBL3115855 0.84 PPARA (0.55) PPARGPPARAPPARD
SCHEMBL3124017 0.83 PPARA (0.57) PPARGPPARAPPARD
SCHEMBL1400910 0.81 PPARA (0.55) PPARGPPARAPPARD
SCHEMBL1400808 0.76 PPARA (0.61) PPARGPPARAPPARD
SCHEMBL1400466 0.74 PPARA (0.60) PPARGPPARAPPARD
SCHEMBL1400647 0.74 PPARA (0.70) PPARGPPARAPPARD
SCHEMBL3023138 0.73 PPARG (0.59) PPARGPPARAPPARD
SCHEMBL1400285 0.72 PPARD (0.64) PPARGPPARAPPARD
SCHEMBL1400782 0.72 PPARD (0.65) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3548023-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D Therapeutics, Inc. (US) 2019-10-09 EP disclosed
WO-2018102399-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-06-07 WO disclosed