Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 16/20 | 0.84 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | INSR | P06213 | 2/20 | 0.62 |
| ▸ | IGF1R | P08069 | 2/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24039985 | 1.00 | MAP4K1 (0.84) | MAP4K1EGFRINSRIGF1RALK | |
| SCHEMBL20214480 | 0.92 | MAP4K1 (0.81) | MAP4K1EGFRINSRIGF1RALK | |
| SCHEMBL24040086 | 0.91 | MAP4K1 (1.00) | MAP4K1EGFRINSRIGF1RALK | |
| SCHEMBL24039954 | 0.91 | MAP4K1 (1.00) | MAP4K1EGFRINSRIGF1RALK | |
| SCHEMBL24040082 | 0.91 | MAP4K1 (1.00) | MAP4K1INSRIGF1RALK | |
| SCHEMBL20214415 | 0.91 | MAP4K1 (1.00) | MAP4K1INSRIGF1RALK | |
| SCHEMBL24039989 | 0.91 | MAP4K1 (0.75) | MAP4K1EGFRINSRIGF1RALK | |
| SCHEMBL24039944 | 0.91 | MAP4K1 (0.75) | MAP4K1EGFRINSRIGF1RALK | |
| SCHEMBL24040064 | 0.90 | MAP4K1 (1.00) | MAP4K1EGFRINSRIGF1RALK | |
| SCHEMBL24039922 | 0.89 | MAP4K1 (1.00) | MAP4K1INSRIGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548479-A1 | ANILINOPYRIMIDINES AS HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS | ARIAD Pharmaceuticals, Inc. (US) | 2019-10-09 | — | — | EP | claimed |
| WO-2018102366-A1 | ANILINOPYRIMIDINES AS HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2018-06-07 | — | — | WO | claimed |