Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.53 |
| ▸ | ITK | Q08881 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29722549 | 0.90 | EGFR (0.67) | EGFRITKBTKJAK3 | |
| SCHEMBL12519719 | 0.90 | EGFR (0.67) | EGFRITKBTKJAK3 | |
| SCHEMBL655690 | 0.81 | SYK (0.57) | EGFRSYKAURKA | |
| SCHEMBL913699 | 0.77 | BRAF (0.55) | SYKPTK2JAK3BRAFAURKA | |
| SCHEMBL654089 | 0.77 | SYK (0.56) | EGFRSYK | |
| SCHEMBL655281 | 0.77 | EGFR (0.69) | EGFRITKSYKBTKCCNT1 | |
| SCHEMBL15586275 | 0.76 | EGFR (0.48) | EGFRITKSYKBTKJAK3 | |
| SCHEMBL915035 | 0.74 | JAK3 (0.63) | EGFRITKSYKJAK3CCNT1 | |
| SCHEMBL914215 | 0.74 | JAK3 (0.68) | EGFRPTK2JAK3BRAF | |
| SCHEMBL655928 | 0.74 | SYK (0.69) | EGFRSYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9987276-B2 | Substituted 2,4-diaminopyrimidines as kinase inhibitors | CELGENE CAR LLC (BM) | 2018-06-05 | — | — | US | disclosed |