Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.74 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3896160 | 0.93 | PDGFRB (0.74) | PDGFRBPDGFRARIPK1ALDH1A1MEN1 | |
| SCHEMBL31187502 | 0.93 | PDGFRB (0.74) | PDGFRBPDGFRARIPK1ALDH1A1MEN1 | |
| SCHEMBL4299023 | 0.85 | PDGFRB (1.00) | PDGFRBPDGFRAALDH1A1TLR8NPC1 | |
| Hydrochloric Acid SCHEMBL29357672 | 0.84 | PDGFRB (0.96) | PDGFRBPDGFRAALDH1A1TLR8NPC1 | |
| SCHEMBL28828230 | 0.81 | PDGFRB (0.53) | PDGFRBPDGFRAALDH1A1MEN1CASP1 | |
| SCHEMBL244602 | 0.81 | PDGFRB (0.77) | PDGFRBPDGFRAALDH1A1MEN1CASP1 | |
| SCHEMBL28157133 | 0.80 | PDGFRB (0.51) | PDGFRBPDGFRAALDH1A1MEN1CASP1 | |
| SCHEMBL16431663 | 0.80 | PDGFRB (0.70) | PDGFRBPDGFRAALDH1A1MEN1CASP1 | |
| SCHEMBL6608733 | 0.79 | PDGFRB (0.74) | PDGFRBPDGFRAALDH1A1MEN1CASP1 | |
| SCHEMBL30074619 | 0.79 | PDGFRB (0.74) | PDGFRBPDGFRAALDH1A1ALOX15HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |
| CN-107778287-A | A kind of compound as tyrosine protein kinase inhibitor | 南昌弘益药业有限公司 | 2018-03-09 | — | — | CN | disclosed |
| CN-107151240-A | Polysubstituted carbostyril compound of one class and its production and use | 中国科学院上海药物研究所 | 2017-09-12 | — | — | CN | disclosed |