Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 5/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217157 | 0.89 | MEN1 (0.54) | MEN1ALDH1A1MAPK1KMT2ASMYD3 | |
| SCHEMBL20217267 | 0.86 | MEN1 (0.56) | MEN1ALDH1A1MAPK1KMT2ASMYD3 | |
| SCHEMBL20217694 | 0.83 | MEN1 (0.47) | MEN1ALDH1A1MAPK1KMT2ASMYD3 | |
| SCHEMBL20217385 | 0.82 | CYP3A4 (0.46) | MEN1ALDH1A1MAPK1KMT2ACDK2 | |
| SCHEMBL20217743 | 0.81 | MEN1 (0.45) | MEN1ALDH1A1MAPK1KMT2ASMYD3 | |
| SCHEMBL20217277 | 0.80 | MEN1 (0.43) | MEN1ALDH1A1MAPK1KMT2ASMYD3 | |
| SCHEMBL20217441 | 0.80 | MAPK1 (0.47) | MEN1ALDH1A1MAPK1KMT2ASMYD3 | |
| SCHEMBL20217369 | 0.76 | KMT2A (0.48) | MEN1ALDH1A1MAPK1KMT2ASMYD3 | |
| SCHEMBL20217236 | 0.76 | HDAC3 (0.44) | MEN1ALDH1A1MAPK1KMT2ASMYD3 | |
| SCHEMBL20217335 | 0.76 | F10 (0.43) | MEN1ALDH1A1MAPK1KMT2ASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |