Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217390 | 0.88 | TTK (0.63) | CYP3A4TTKAURKBINCENPSLC6A2 | |
| SCHEMBL20217361 | 0.86 | HRH3 (0.43) | CYP3A4TTKKCNH2LMNACHRM2 | |
| SCHEMBL20217664 | 0.83 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPSLC6A2 | |
| SCHEMBL20217592 | 0.80 | CYP3A4 (0.53) | CYP3A4TTKAURKBINCENPSLC6A2 | |
| SCHEMBL20217349 | 0.79 | CYP3A4 (0.50) | CYP3A4TTKAURKBINCENPSLC6A2 | |
| SCHEMBL20217458 | 0.79 | CYP3A4 (0.50) | CYP3A4TTKAURKBINCENPSLC6A2 | |
| SCHEMBL20217755 | 0.78 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPSLC6A2 | |
| SCHEMBL20217221 | 0.77 | TTK (0.51) | CYP3A4TTKAURKBINCENPF10 | |
| SCHEMBL20217781 | 0.77 | CYP3A4 (0.41) | CYP3A4TTKAURKBINCENPOPRK1 | |
| SCHEMBL16296497 | 0.77 | TTK (0.80) | CYP3A4TTKAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |