Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21769120 | 0.90 | CYP1A2 (0.41) | TLR8TLR7CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL15469708 | 0.89 | TLR8 (0.44) | TLR8TLR7MRGPRX4RAB9ASMN1; SMN2 | |
| SCHEMBL20418680 | 0.80 | HTR2A (0.34) | TLR8 | |
| SCHEMBL13195812 | 0.78 | TLR7 (0.59) | TLR8TLR7MRGPRX4RAB9ASMN1; SMN2 | |
| SCHEMBL13195019 | 0.77 | TLR7 (0.46) | TLR8TLR7CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL20219584 | 0.70 | CYP1A2 (0.34) | TLR8TLR7CYP1A2CYP2D6 | |
| SCHEMBL15469709 | 0.69 | CYP2D6 (0.42) | TLR8TLR7MRGPRX4CYP1A2CYP2D6 | |
| SCHEMBL20219392 | 0.69 | CYP1A2 (0.46) | TLR8TLR7MRGPRX4RAB9ASMN1; SMN2 | |
| SCHEMBL15469710 | 0.69 | TLR8 (0.39) | TLR8TLR7CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL15469973 | 0.68 | CYP1A2 (0.54) | TLR8TLR7MRGPRX4RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |