Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13195751 | 1.00 | CYP2D6 (0.56) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL13195845 | 0.93 | TLR7 (0.63) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL19269139 | 0.93 | TLR7 (0.63) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL13195144 | 0.93 | TLR7 (0.63) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL13195743 | 0.91 | TLR8 (0.53) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL13195695 | 0.91 | TLR8 (0.53) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL13195820 | 0.91 | TLR8 (0.53) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL19269129 | 0.89 | KCNH2 (0.52) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL23472404 | 0.88 | TLR7 (0.51) | CYP2D6DRD1HTR2AADORA1TLR7 | |
| SCHEMBL20418730 | 0.88 | CYP2D6 (0.49) | CYP2D6DRD1HTR2AADORA1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-2694484-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2018-07-18 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |