Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15470284 | 1.00 | TLR7 (0.56) | TLR7TLR8CYP1A2CYP3A4TRPM8 | |
| SCHEMBL15470317 | 1.00 | TLR7 (0.56) | TLR7TLR8CYP1A2CYP3A4TRPM8 | |
| SCHEMBL20386804 | 0.91 | TLR7 (0.67) | TLR7TLR8CYP1A2CYP3A4KCNH2 | |
| SCHEMBL23472191 | 0.89 | TLR7 (0.48) | TLR7TLR8CYP1A2CYP3A4TRPM8 | |
| SCHEMBL23472577 | 0.88 | TLR7 (0.47) | TLR7TLR8CYP1A2CYP3A4TRPM8 | |
| SCHEMBL20219353 | 0.87 | TLR8 (0.66) | TLR7TLR8CYP1A2CYP3A4 | |
| SCHEMBL15470197 | 0.87 | TLR8 (0.66) | TLR7TLR8CYP1A2CYP3A4 | |
| SCHEMBL13195815 | 0.86 | TLR7 (0.75) | TLR7TLR8CYP1A2CYP3A4KCNH2 | |
| SCHEMBL13195734 | 0.84 | TLR7 (0.59) | TLR7TLR8CYP1A2CYP3A4KCNH2 | |
| SCHEMBL13194973 | 0.83 | CYP1A2 (0.69) | TLR7TLR8CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |