Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472609 | 0.93 | KCNH2 (0.37) | TLR7TLR8KCNH2 | |
| SCHEMBL20413268 | 0.83 | TLR7 (0.42) | TLR7TLR8KCNH2 | |
| SCHEMBL20219667 | 0.83 | TLR7 (0.51) | TLR7TLR8KCNH2 | |
| SCHEMBL15470387 | 0.83 | TLR7 (0.51) | TLR7TLR8KCNH2 | |
| SCHEMBL19269130 | 0.83 | TLR7 (0.51) | TLR7TLR8KCNH2 | |
| SCHEMBL23472420 | 0.81 | CYP2D6 (0.39) | TLR7TLR8KCNH2 | |
| SCHEMBL23472496 | 0.80 | TLR7 (0.39) | TLR7TLR8KCNH2 | |
| SCHEMBL20219778 | 0.80 | TLR7 (0.41) | TLR7TLR8KCNH2 | |
| SCHEMBL20219780 | 0.79 | CYP11B1 (0.35) | TLR8KCNH2 | |
| SCHEMBL23472389 | 0.79 | KCNH2 (0.47) | TLR7TLR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |