Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15470285 | 1.00 | TLR7 (0.44) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL15470282 | 1.00 | TLR7 (0.44) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL23472299 | 0.89 | NPC1 (0.44) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL15470199 | 0.88 | TLR8 (0.44) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL15470178 | 0.87 | KCNH2 (0.46) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL15470210 | 0.84 | TLR8 (0.47) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL13195702 | 0.84 | TLR7 (0.60) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL15470181 | 0.84 | KCNH2 (0.48) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL19274232 | 0.79 | SMN1; SMN2 (0.41) | TLR7SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL19274250 | 0.79 | SMN1; SMN2 (0.43) | TLR7SMN1; SMN2NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |