Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472532 | 0.95 | TLR7 (0.44) | TLR8TLR7KCNH2PDE5A | |
| SCHEMBL15470311 | 0.91 | TLR8 (0.48) | TLR8TLR7KCNH2PDE5A | |
| SCHEMBL15469727 | 0.91 | TLR8 (0.46) | TLR8TLR7KCNH2PDE5A | |
| SCHEMBL23472350 | 0.91 | TLR8 (0.46) | TLR8TLR7KCNH2PDE5A | |
| SCHEMBL23472539 | 0.88 | TLR8 (0.46) | TLR8TLR7KCNH2PDE5A | |
| SCHEMBL15470315 | 0.85 | TLR8 (0.45) | TLR8TLR7KCNH2PDE5A | |
| SCHEMBL20386712 | 0.85 | TLR8 (0.45) | TLR8TLR7KCNH2PDE5A | |
| SCHEMBL15470299 | 0.85 | TLR8 (0.45) | TLR8TLR7KCNH2PDE5A | |
| SCHEMBL15470177 | 0.85 | TLR8 (0.49) | TLR8TLR7KCNH2 | |
| SCHEMBL21769265 | 0.85 | KCNH2 (0.47) | TLR8TLR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |