Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20054596 | 0.93 | SMN1; SMN2 (0.43) | SMN1; SMN2CACNA1HCACNA1GTSHRMAPK10 | |
| SCHEMBL16444172 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2CACNA1HCACNA1GTSHRMAPK10 | |
| SCHEMBL15584680 | 0.75 | CACNA1H (0.48) | SMN1; SMN2CACNA1HCACNA1GTSHRMAPK10 | |
| SCHEMBL15584675 | 0.74 | CACNA1H (0.47) | SMN1; SMN2CACNA1HCACNA1GTSHRMAPK10 | |
| SCHEMBL12066792 | 0.73 | CACNA1H (0.50) | SMN1; SMN2CACNA1HCACNA1GTSHRMAPK10 | |
| SCHEMBL16882383 | 0.73 | CACNA1H (0.50) | SMN1; SMN2CACNA1HCACNA1BKMT2AGSK3B | |
| SCHEMBL16444723 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2CACNA1HCACNA1GTSHRMAPK10 | |
| SCHEMBL19388574 | 0.71 | SCN10A (0.35) | GSK3BCSNK1A1CSNK1DCSNK1G2ALDH1A1 | |
| SCHEMBL15116840 | 0.71 | SCN10A (0.35) | GSK3BCSNK1A1CSNK1DCSNK1G2ALDH1A1 | |
| SCHEMBL11296984 | 0.71 | SMN1; SMN2 (0.76) | SMN1; SMN2KMT2APOLBALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019196-B1 | COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-06 | — | — | EP | disclosed |