SCHEMBL20224488

SCHEMBL20224488

c1ccc(-c2cc(-c3ccc4c(c3)C3(c5ccccc5-c5ccccc5-4)c4ccccc4-c4c3ccc3oc5ccccc5c43)nc(-c3ccc(-c4cccnc4)nc3)n2)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.34
HDAC6 Q9UBN7 2/20 0.34
DHODH Q02127 1/20 0.33
HSD17B10 Q99714 2/20 0.32
CYP19A1 P11511 1/20 0.32
ALDH1A1 P00352 3/20 0.32
RAB9A P51151 2/20 0.32
TSHR P16473 2/20 0.32
GAA P10253 2/20 0.32
GPR84 Q9NQS5 1/20 0.32
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
GBA1 P04062 1/20 0.31
CYP3A4 P08684 2/20 0.31
CYP2C9 P11712 2/20 0.31
MAPT P10636 2/20 0.31
KDM4E B2RXH2 1/20 0.31
HPGD P15428 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PIM1 P11309 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20224494 0.98 PDK2 (0.35) PDK2HDAC6DHODHHSD17B10CYP19A1
SCHEMBL20224487 0.98 PDK2 (0.35) PDK2HDAC6DHODHHSD17B10CYP19A1
SCHEMBL20224497 0.94 PDK2 (0.37) PDK2DHODHHSD17B10CYP19A1ALDH1A1
SCHEMBL20224486 0.93 PDK2 (0.37) PDK2DHODHHSD17B10CYP19A1ALDH1A1
SCHEMBL20224489 0.92 PDK2 (0.38) PDK2DHODHHSD17B10CYP19A1ALDH1A1
SCHEMBL20224481 0.92 PDK2 (0.38) PDK2DHODHHSD17B10CYP19A1ALDH1A1
SCHEMBL20224491 0.92 PDK2 (0.39) PDK2DHODHHSD17B10CYP19A1ALDH1A1
SCHEMBL19862250 0.91 HDAC6 (0.33) PDK2HDAC6DHODHCYP19A1GPR84
SCHEMBL20224301 0.90 PDK2 (0.34) PDK2HDAC6DHODHHSD17B10CYP19A1
SCHEMBL19862255 0.89 HDAC6 (0.33) PDK2HDAC6DHODHCYP19A1GPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180159044-A1 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME NICHEM FINE TECHNOLOGY CO., LTD. (TW) 2018-06-07 US disclosed
US-20180159044-A1 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME NICHEM FINE TECHNOLOGY CO., LTD. (TW) 2018-06-07 US disclosed