Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 17/20 | 0.72 |
| ▸ | CCNH | P51946 | 16/20 | 0.72 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNK | O75909 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.55 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.55 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.50 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20225385 | 0.86 | CDK7 (0.82) | CDK7CCNHMNAT1CDK5CDK5R1 | |
| SCHEMBL18313301 | 0.84 | CDK7 (1.00) | CDK7CCNHMNAT1CDK5CDK5R1 | |
| SCHEMBL20225381 | 0.84 | MAPK8 (0.69) | CDK7CCNHMNAT1CDK5CDK5R1 | |
| SCHEMBL20225382 | 0.82 | CDK7 (0.75) | CDK7CCNHMNAT1CDK5CDK5R1 | |
| SCHEMBL20225388 | 0.81 | PIP4K2A (0.66) | CDK7CCNHMAPK8MAPK9MAPK10 | |
| SCHEMBL20225393 | 0.78 | CDK7 (0.52) | CDK7CCNHMNAT1MAPK8MAPK9 | |
| SCHEMBL20211533 | 0.78 | CDK7 (0.63) | CDK7CCNHMNAT1CDK5CDK5R1 | |
| SCHEMBL20211532 | 0.78 | CDK7 (0.63) | CDK7CCNHMNAT1CDK5CDK5R1 | |
| SCHEMBL18313112 | 0.77 | CDK7 (1.00) | CDK7CCNHMNAT1CDK5CDK5R1 | |
| SCHEMBL20211546 | 0.77 | CDK7 (0.52) | CDK7CCNHMNAT1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10342798-B2 | Fused bicyclic pyrimidine derivatives and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-20180153894-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-06-07 | — | — | US | disclosed |
| US-20180153894-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10342798-B2 | Fused bicyclic pyrimidine derivatives and uses thereof | CDK3, CDK14, CDK1 | CDK7 5/4885CCNH 65/4885MNAT1 646/4885 |
| US-20180153894-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF | CDK3, CDK14, CDK1 | CDK7 5/4885CCNH 65/4885MNAT1 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.