Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 6/20 | 0.52 |
| ▸ | CCNH | P51946 | 5/20 | 0.52 |
| ▸ | PIP4K2A | P48426 | 4/20 | 0.45 |
| ▸ | PIP4K2B | P78356 | 4/20 | 0.45 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18346151 | 0.94 | CDK7 (0.56) | CDK7CCNHPIP4K2APIP4K2BBTK | |
| SCHEMBL20225384 | 0.85 | CDK7 (0.75) | CDK7CCNHPIP4K2APIP4K2BCDK1 | |
| SCHEMBL18313107 | 0.78 | CDK7 (0.76) | CDK7CCNHPIP4K2APIP4K2BBTK | |
| SCHEMBL14979755 | 0.76 | PDGFRA (0.59) | CDK7CCNHPIP4K2APIP4K2BBTK | |
| SCHEMBL18346307 | 0.75 | CDK7 (0.43) | CDK7CCNHBTKITKPDGFRA | |
| SCHEMBL20228952 | 0.75 | CDK7 (0.63) | CDK7CCNHPIP4K2APIP4K2BCDK1 | |
| SCHEMBL18346365 | 0.74 | CDK7 (0.55) | CDK7CCNHPIP4K2APIP4K2BPIKFYVE | |
| SCHEMBL18346338 | 0.73 | CDK7 (0.50) | CDK7CCNHPIP4K2APIP4K2BPIKFYVE | |
| SCHEMBL23609231 | 0.73 | CDK7 (0.67) | CDK7CCNHPIP4K2APIP4K2BBTK | |
| SCHEMBL20228962 | 0.72 | CDK7 (0.79) | CDK7CCNHPIP4K2APIP4K2BCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180153894-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180153894-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF | CDK3, CDK14, CDK1 | CDK7 5/4885CCNH 65/4885PIP4K2A 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.