Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26042560 | 1.00 | MAPK1 (0.46) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL21636026 | 1.00 | MAPK1 (0.46) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL21636086 | 1.00 | MAPK1 (0.46) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL21636107 | 0.99 | MAPK1 (0.45) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL21636025 | 0.97 | MAPK1 (0.44) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL21636068 | 0.95 | MAPK1 (0.46) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL21636052 | 0.95 | MAPK1 (0.49) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL21636059 | 0.93 | MAPK1 (0.49) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL20227636 | 0.93 | MAPK1 (0.49) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 | |
| SCHEMBL21636000 | 0.93 | MAPK1 (0.49) | MAPK1KMT2ANPSR1L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3823958-B1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2023-08-23 | — | — | EP | disclosed |
| US-11713319-B2 | Compounds having valerolactam structures | MERCK PATENT GMBH (DE) | 2023-08-01 | — | — | US | disclosed |
| US-11713319-B2 | Compounds having valerolactam structures | MERCK PATENT GMBH (DE) | 2023-08-01 | — | — | US | disclosed |
| US-20200031827-A1 | COMPOUNDS HAVING VALEROLACTAM STRUCTURES | MERCK PATENT GMBH (DE) | 2020-01-30 | — | — | US | disclosed |
| WO-2018099846-A1 | COMPOUNDS HAVING VALEROLACTAM STRUCTURES | MERCK PATENT GMBH (DE) | 2018-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11713319-B2 | Compounds having valerolactam structures | ACE, CYP3A4, CYP2D6 | MAPK1 2970/4885KMT2A 1161/4885NPSR1 1778/4885 |
| US-20200031827-A1 | COMPOUNDS HAVING VALEROLACTAM STRUCTURES | ACE, CYP3A4, CYP2D6 | MAPK1 2970/4885KMT2A 1161/4885NPSR1 1778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.